Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants
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چکیده
منابع مشابه
Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants
The generation of excess reactive oxygen species (ROS) in mitochondria is responsible for much of the oxidative stress associated with ageing (aging), and mitochondrial dysfunction is part of the pathology of neurodegeneration and type 2 diabetes. Lipophilic pyridinium ions are known to accumulate in mitochondria and this paper describes a general route for the preparation of nitrone-containing...
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N-Oxidation of 1,4-dihydro-2,6-dimethyl-1- phenyliminopyridine (7) with several peracids was attempted. The main compound obtained was l-phenyl- 2,6-dimethyl-4-pyridone (8), instead of the expected N-oxide (2). The reaction of phenylhydroxylamine with dimthylrnethoxypyroxonium perchlorate, however, successfully gave the N-oxide (3), which belongs to a class of nitrones in which the diazomet...
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2009
ISSN: 0040-4020
DOI: 10.1016/j.tet.2009.04.083